Focal Segmantal Glomerulosclerosis: Epidemiological, Clinico-Biological, Pathological, Etiological, Therapeutic and Evolutionary Profiles in Dakar

Introduction: Focal Segmental Glomerulosclerosis (FSGS) corresponds to a clinicopathological syndrome, manifested by generally abundant proteinuria associated with hyaline deposits on part of certain glomeruli and sparing other glomeruli, effacement the pedicels. The general objective was determine prevalence FSGS, give its profiles; epidemiological, clinical, biological, pathological, etiological, therapeutic evolutionary FSGS. Materials Methods: This is retrospective analytical study over period six years extending from January 1, 2010 December 31, 2015 patients aged 16 or who were hospitalized received consultations during for primary secondary segmental focal hyalinosis. Patients whose records incomplete unusable not included in study. Results: We have 16.54% 158 cases FSGS out 6945 and/or hospitalized. Of 955 kidney biopsies distributed, incidences HSF were; 10.15%; 14.04%; 15%; 17.64%; 20.11%; 19.58% respectively 2010; 2011; 2012; 2013; 2014 2015, i.e. an annual increase around 1.25%. Renal-type edemas found 93.3%, first reason hospitalization. And ninety-six people had impaired function, 61%. average 24-hour 6.4 ± 3.69 g/24 hours. extremes 0.37 18.50 g/24h. nephrotic 84.86%. Non-specific NOS (Not Other Specificities) 62 39.24%, collapsing 48 30.40%. causes fibrosis 5/35 cases. Collapsing FSGSs followed most corticosteroid-resistant. evolution reveals that every 8 months decreases half. Conclusion: hyalinosis requires histological confirmation clinico-biological, profiles depend (pathological) type. works risk factors occurrence contribution electron microscopy diagnosis are desired.